The 2022 update of the Canadian Stroke Best Practice Recommendations (CSBPR) for
Acute Stroke Management, 7th edition, is a comprehensive summary of current evidence-based …

BACKGROUND Although the aerobic profile of the quadriceps muscle is reduced in COPD,
there is conflicting evidence regarding whether this leads to reduced quadriceps muscle …

Background The use of opioids for noncancer pain is widespread, and more than 16,000 die
of opioid-related causes in the United States annually. The patients at greatest risk of death …

Oral anticoagulation therapy is widely used for stroke prevention in patients with atrial
fibrillation or mechanical heart valves, as well as for the treatment and prevention of venous …

Patients with widespread atherosclerosis such as peripheral artery disease (PAD) have a
high risk of cardiovascular and limb symptoms and complications, which affects their quality of …

Importance Patients with symptomatic lower extremity peripheral artery disease (LE-PAD)
experience an increased risk of major vascular events. There is limited information on what …

Background In the PAUSE (Perioperative Anticoagulant Use for Surgery Evaluation) Study,
a simple, standardized, perioperative interruption strategy was provided for patients with …

Background The use of anticoagulants is ubiquitous in outpatient medical practice, with
anticoagulants now among the most common classes of medications prescribed in the United …

Purpose of Review Peripheral artery disease (PAD) affects an estimated 200 million people
worldwide and is associated with significant cardiovascular morbidity and mortality. …

Patients with peripheral artery disease (PAD) are at high risk for ischemic cardiovascular
complications. While single antiplatelet therapy (SAPT), predominantly aspirin, has long been …