Tumor recurrence following treatment remains a major clinical challenge. Evidence from
xenograft models and human trials indicates selective enrichment of cancer-initiating cells (CICs…

The aim of this study was to ascertain the level of concordance among gastrointestinal
pathologists for regression grading in rectal cancers treated with neoadjuvant chemoradiation. …

Aim Several regression grading systems have been proposed for neoadjuvant
chemoradiation-treated pancreatic ductal adenocarcinoma (PDAC). This study aimed to examine the …

BACKGROUND: Many consider histology to be the gold standard forHelicobacter pyloridetection.
Because the number and distribution ofH pyloriorganisms vary, particularly in patients …

Introduction Coeliac disease (CD) is an autoimmune condition characterised by gluten-induced
intestinal inflammation, and observed at a 5–10 fold greater prevalence in type 1 …

Purpose: Cancer-initiating cells (C-IC) have been described in multiple cancer types, including
colorectal cancer. C-ICs are defined by their capacity to self-renew, thereby driving tumor …

von Hippel–Lindau (VHL) disease is a hereditary autosomal dominant disorder associated
with deletions or mutations in the VHL tumor suppressor gene. Characteristically, up to 60 % …

This study aimed to ascertain views, incidence of reporting and diagnostic criteria for gastric
foveolar dysplasia. A questionnaire, a post-questionnaire discussion and microscopic …

To ascertain the approach and degree of consensus of pathologists in the handling and
regression grading of colorectal cancer resection specimens treated with neoadjuvant …

In this issue of the Journal of Clinical Pathology, MacGregor, Maughan and Sharma1 discuss
the value and utility of pathological grading of regression from an oncologist’s point of view…