Efforts to selectively target and disrupt established tumor vasculature have largely failed to
date. We hypothesized that a vaccinia virus engineered to target cells with activation of the ras…

Background The growing volume of studies of robot-assisted nipple-sparing mastectomy
requires critical assessment. This review synthesizes the data on safety, feasibility, oncological …

Puprpose Benign polyps that are technically challenging and unsafe to remove via
polypectomy are known as complex polyps. Concerns regarding safety and completeness of …

Simple Summary Regulatory CD4 + T cell (Treg) is one of the suppressive immune cells, but
data on its clinical relevance in large human breast cancer cohort is limited. Abundance of …

Blood supply within a tumor drives progression and ultimately allows for metastasis. Many
anticancer therapies target tumor vasculature, but their individual effectiveness is limited …

Oncolytic viruses designed to attack malignant cells can in addition infect and destroy tumor
vascular endothelial cells. We show here that this expanded tropism of oncolytic vaccinia …

Background Primary neuroendocrine carcinoma of the breast is a heterogeneous group of
rare tumors with positive immunoreactivity to neuroendocrine markers in at least 50% of cells. …

Cancer-associated adipocytes are known to cause inflammation; however, the role of
adipogenesis, the formation of adipocytes, in breast cancer is unclear. We hypothesized that intra-…

Simple Summary Over 70% of breast cancer patients in the US have estrogen receptor (ER)-positive
tumors. A better predictive biomarker of endocrine therapy would be useful to …

Patients with triple negative breast cancer (TNBC) have a poor prognosis. A novel prognostic
biomarker may guide management by appropriately selecting patients for particular …