Fibrosis is the abnormal deposition of extracellular matrix, which can lead to organ dysfunction,
morbidity, and death. The disease burden caused by fibrosis is substantial, and there are …

Nasopharyngeal carcinoma (NPC) differs from other head and neck cancers in its aetiology,
epidemiology and potential therapeutic options. Despite cure for the majority of the patients, …

Nasopharyngeal carcinoma (NPC) is a unique epithelial malignancy arising from the
superior aspect of the pharyngeal mucosal space, associated with latent Epstein-Barr virus …

In cancer treatment, apoptosis is a well-recognized cell death mechanism through which
cytotoxic agents kill tumor cells. Here we report that dying tumor cells use the apoptotic process …

Results: We report on pretreatment characteristics, the treatments received, the local response
observed, duration of response, time to local failure, distant progression and survival, and …

… Dawson, Andrew Hope, John Cho, Jonathan Irish, Ralph Gilbert, Patrick Gullane, Angela
Hui, Fei-Fei Liu, Eric Chen, and Wei Xu … Financial support: Brian O’Sullivan, Patrick …

The phosphatidylinositol 3′ kinase (PI3′K) pathway, which regulates cell survival, is
antagonized by the PTEN tumor suppressor. The regulation of PTEN is unclear. A genetic screen …

Background Adjuvant radiotherapy is prescribed after breast-conserving surgery to reduce
the risk of local recurrence. However, radiotherapy is inconvenient, costly, and associated …

Purpose: The objective of this study is to investigate the significance of microRNAs (miRNA)
in patients with locally advanced head and neck squamous cell carcinoma (HNSCC). …

Background: Stimuli that stress cells, including inflammatory cytokines, ultra-violet irradiation,
DNA-damaging chemotherapeutic drugs and heat shock, stimulate a recently identified …