TRAF2 is an intracellular signal-transducing protein recruited to the TNFR1 and TNFR2
receptors following TNF stimulation. To investigate the physiological role of TRAF2, we …

Mutations of the BRCA1 gene in humans are associated with predisposition to breast and
ovarian cancers. We show here that Brca1 +/− mice are normal and fertile and lack tumors by …

Resident macrophages orchestrate homeostatic, inflammatory, and reparative activities. It is
appreciated that different tissues instruct specialized macrophage functions. However, …

Oxidative stress is caused by an imbalance between reactive oxygen species (ROS) production
and the ability of an organism to eliminate these toxic intermediates. Mutations in PTEN-…

Given the established anti-inflammatory properties of mesenchymal stromal cells (MSCs),
we investigated their effect on inflammatory cell infiltration of ischemic cardiac tissue and …

Background— Cardiac consequences of obesity include inflammation, hypertrophy, and
compromised energy metabolism. Glucagon-like peptide-1 is an incretin hormone capable of …

Aims This study aimed to review the performance of machine learning (ML) methods compared
with conventional statistical models (CSMs) for predicting readmission and mortality in …

Background: Right ventricular failure (RVF) is a cause of major morbidity and mortality after
left ventricular assist device (LVAD) implantation. It is, therefore, integral to identify patients …

Venoarterial (VA) and venovenous (VV) extracorporeal membrane oxygenation (ECMO)
support is increasingly being used in recent years in the adult population. Owing to the …

Hypertension affects one-third of the world's population, leading to cardiac dysfunction that
is modulated by resident and recruited immune cells. Cardiomyocyte growth and increased …