Background Studies that have evaluated the use of intravenous vitamin C in adults with
sepsis who were receiving vasopressor therapy in the intensive care unit (ICU) have shown …

… François Lauzier and Jean-François Simard were involved in the drafting of the manuscript.
Alexis Turgeon, François Lauzier, Jean-François … Lauzier are recipients of a research career …

Importance Growing interest in microbial dysbiosis during critical illness has raised
questions about the therapeutic potential of microbiome modification with probiotics. Prior …

Introduction Plusieurs strategies ont ete proposees pour le contrôle de la douleur postoperatoire.
Parmi ces strategies, la lidocaıne par voie intraveineuse suscite un intereˆt croissant. …

Background Widely used for acute pain management, the clinical benefit from perioperative
use of gabapentinoids is uncertain. The aim of this systematic review was to assess the …

Background The clinical significance of elevated cardiac troponin (cTn) level in patients in
the intensive care unit (ICU) is uncertain. We reviewed the frequency of cTn elevation and its …

Objective To compare the effects of arginine-vasopressin (AVP) and norepinephrine (NE)
on hemodynamic variables, organ dysfunction, and adverse events in early hyperdynamic …

Purpose In shock, hypotension may contribute to inadequate oxygen delivery, organ failure
and death. We conducted the Optimal Vasopressor Titration (OVATION) pilot trial to inform …

Background Thrombocytopenia is the most common hemostatic disorder in critically ill patients.
The objective of this study was to describe the incidence, risk factors, and outcomes of …

Objectives To determine the ability and accuracy of the S-100β protein in predicting prognosis
after a moderate or severe traumatic brain injury. Design Systematic review and meta-…