A main pathway used by cytotoxic T lymphocytes (CTLs) and natural killer cells to eliminate
pathogenic cells is via exocytosis of granule components in the direction of the target cell, …

… Inhaled pentamidine (300 mg once a month) was given after transplantation to prevent
infection with Pneumocystis carinii, and oral ganciclovir (1 g three times per day) was given for 14 …

Many sites have been tested in an effort to identify the most ideal site to support islet
function and viability. The aim of this study was to evaluate an omental pouch site for islet …

Background Islet transplantation offers the potential to improve glycemic control in a subgroup
of patients with type 1 diabetes mellitus who are disabled by refractory hypoglycemia. We …

Islet transplantation offers the prospect of good glycemic control without major surgical risks.
After our initial report of successful islet transplantation, we now provide further data on 12 …

… Our results show that whereas AIR g and AUC i were closely related, there was no significant
relationship of AIR g and AIR arg in control subjects or study subjects. Thus whereas both …

We evaluated the ability of neonatal porcine islets to engraft and restore glucose control in
pancreatectomized rhesus macaques. Although porcine islets transplanted into …

… cellular insulin mass of 38.4 g required 5 wk to normalize diabetic nude mice (15). In the
present study, only 2,000 porcine NIC aggregates containing 4 g insulin were required to …

… For oral glucose tolerance tests, glucose was administered orally by feeding tube (1.5 g/kg
body weight) as a 50% solution (w/v) to mice that had been without food for 14 hours. Blood …

The aim of the present study was to clarify whether prolonged in vitro exposure of human
pancreatic islets to high glucose concentrations impairs the function of these cells. For this …