Using a multistage genetic association approach comprising 7,480 affected individuals and
7,779 controls, we identified markers in chromosomal region 8q24 associated with colorectal …

Importance E-cadherin (CDH1) is a cancer predisposition gene mutated in families meeting
clinically defined hereditary diffuse gastric cancer (HDGC). Reliable estimates of cancer risk …

Pancreatic cancer, a highly aggressive tumour type with uniformly poor prognosis,
exemplifies the classically held view of stepwise cancer development 1 . The current model of …

PURPOSE To estimate age-specific relative and absolute cancer risks of breast cancer and
to estimate risks of ovarian, pancreatic, male breast, prostate, and colorectal cancers …

Pancreatic adenocarcinoma presents as a spectrum of a highly aggressive disease in patients.
The basis of this disease heterogeneity has proved difficult to resolve due to poor tumor …

Pancreatic cancer is projected to become the second leading cause of cancer-related death
in the United States by 2020. A familial aggregation of pancreatic cancer has been …

Purpose: To determine the impact of basal-like and classical subtypes in advanced
pancreatic ductal adenocarcinoma (PDAC) and to explore GATA6 expression as a surrogate …

We integrated clinical, genomic, and transcriptomic data from 224 primaries and 95 metastases
from 289 patients to characterize progression of pancreatic ductal adenocarcinoma (…

Background and Aims Homologous recombination deficiency (HRD) in pancreatic ductal
adenocarcinoma (PDAC), remains poorly defined beyond germline (g) alterations in BRCA1, …

Purpose: The molecular drivers of antitumor immunity in pancreatic ductal adenocarcinoma (PDAC)
are poorly understood, posing a major obstacle for the identification of patients …