User profiles for Guillaume Butler-Laporte
 | Guillaume Butler-LaporteMcGill University Verified email at mail.mcgill.ca Cited by 3255 |
Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases
…, U Pettersson-Kymmer, ID Stewart, G Butler-Laporte… - Nature …, 2023 - nature.com
Metabolic processes can influence disease risk and provide therapeutic targets. By conducting
genome-wide association studies of 1,091 blood metabolites and 309 metabolite ratios, …
genome-wide association studies of 1,091 blood metabolites and 309 metabolite ratios, …
[HTML][HTML] A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity
To identify circulating proteins influencing Coronavirus Disease 2019 (COVID-19) susceptibility
and severity, we undertook a two-sample Mendelian randomization (MR) study, rapidly …
and severity, we undertook a two-sample Mendelian randomization (MR) study, rapidly …
Comparison of saliva and nasopharyngeal swab nucleic acid amplification testing for detection of SARS-CoV-2: a systematic review and meta-analysis
G Butler-Laporte, A Lawandi, I Schiller… - JAMA internal …, 2021 - jamanetwork.com
Importance Nasopharyngeal swab nucleic acid amplification testing (NAAT) is the noninvasive
criterion standard for diagnosis of coronavirus disease 2019 (COVID-19). However, it …
criterion standard for diagnosis of coronavirus disease 2019 (COVID-19). However, it …
[HTML][HTML] Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19
The OAS1/2/3 cluster has been identified as a risk locus for severe COVID-19 among
individuals of European ancestry, with a protective haplotype of approximately 75 kilobases (kb) …
individuals of European ancestry, with a protective haplotype of approximately 75 kilobases (kb) …
[HTML][HTML] Staphylococcus aureus bacteraemia mortality: a systematic review and meta-analysis
…, I Stefanova, C Fogarty, G Butler-Laporte… - Clinical Microbiology …, 2022 - Elsevier
Background Precise estimates of mortality in Staphylococcus aureus bacteraemia (SAB) are
important to convey prognosis and guide the design of interventional studies. Objectives We …
important to convey prognosis and guide the design of interventional studies. Objectives We …
[HTML][HTML] Vitamin D and COVID-19 susceptibility and severity in the COVID-19 Host Genetics Initiative: A Mendelian randomization study
Background Increased vitamin D levels, as reflected by 25-hydroxy vitamin D (25OHD)
measurements, have been proposed to protect against COVID-19 based on in vitro, observational…
measurements, have been proposed to protect against COVID-19 based on in vitro, observational…
[HTML][HTML] Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality
…, M Cordioli, G Butler-Laporte… - The Journal of …, 2021 - Am Soc Clin Investig
Background There is considerable variability in COVID-19 outcomes among younger adults,
and some of this variation may be due to genetic predisposition. Methods We combined …
and some of this variation may be due to genetic predisposition. Methods We combined …
[PDF][PDF] Pan-ancestry exome-wide association analyses of COVID-19 outcomes in 586,157 individuals
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes coronavirus disease
2019 (COVID-19), a respiratory illness that can result in hospitalization or death. We used …
2019 (COVID-19), a respiratory illness that can result in hospitalization or death. We used …
[HTML][HTML] Diagnostic accuracy of serum (1-3)-β-D-glucan for Pneumocystis jirovecii pneumonia: a systematic review and meta-analysis
O Del Corpo, G Butler-Laporte, DC Sheppard… - Clinical Microbiology …, 2020 - Elsevier
Background Pneumocystis jirovecii pneumonia (PJP) can be a life-threatening opportunistic
infection in immunocompromised hosts. The diagnosis can be challenging, often requiring …
infection in immunocompromised hosts. The diagnosis can be challenging, often requiring …
[HTML][HTML] Rare loss-of-function variants in type I IFN immunity genes are not associated with severe COVID-19
A recent report found that rare predicted loss-of-function (pLOF) variants across 13 candidate
genes in TLR3- and IRF7-dependent type I IFN pathways explain up to 3.5% of severe …
genes in TLR3- and IRF7-dependent type I IFN pathways explain up to 3.5% of severe …