Lynch syndrome, which is now recognized as the most common hereditary colorectal
cancer condition, is characterized by the predisposition to a spectrum of cancers, primarily …

More than one million patients will manifest colorectal cancer (CRC) this year of which,
conservatively, approximately 3% (∼30,700 cases) will have Lynch syndrome (LS), the most …

Genetic epidemiology studies of colorectal cancer (CRC) can identify persons who are at
inordinately high risk and who thereby might benefit from targeted early detection and primary …

… One of the first successful efforts of the International Collaborative Group on HNPCC (ICG-HNPCC)
at its meeting in Amsterdam in 1990 was the establishment of a set of selection criteria for …

Background Women with the Lynch syndrome (hereditary nonpolyposis colorectal cancer)
have a 40 to 60 percent lifetime risk of endometrial cancer and a 10 to 12 percent lifetime risk …

BACKGROUND Hereditary nonpolyposis colorectal cancer (HNPCC) dates to Aldred Warthin's
description of Family G a century ago. The phenotype features an excess of early onset …

Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is a
common autosomal dominant syndrome characterized by early age at onset, neoplastic …

… Arbor, reported the first family with the disease we now call Lynch Syndrome (Fig. 1). In 1895,
a … One person who noted these familial clusters of cancer was Henry T. Lynch, MD, who …

Persons with the Lynch syndrome (LS) are at high risk for cancer, including cancers of the
small bowel, stomach, upper urologic tract (renal pelvis and ureter), ovary, biliary tract and …

Lynch syndrome (LS) is the most common of all inherited cancer syndromes, associated
with substantially elevated risks for colonic and extracolonic malignancies, earlier onset and …