User profiles for Hunter Moore
 | Hunter MooreAdventHealth Porter Transplant Institution Verified email at adventhealth.com Cited by 9687 |
Tissue plasminogen activator (tPA) treatment for COVID‐19 associated acute respiratory distress syndrome (ARDS): a case series
A prothrombotic coagulopathy is commonly found in critically ill COVID‐19 patients with acute
respiratory distress syndrome (ARDS). A unique feature of COVID‐19 respiratory failure is …
respiratory distress syndrome (ARDS). A unique feature of COVID‐19 respiratory failure is …
Fibrinolysis shutdown correlation with thromboembolic events in severe COVID-19 infection
Background COVID-19 predisposes patients to a prothrombotic state with demonstrated
microvascular involvement. The degree of hypercoagulability appears to correlate with outcomes…
microvascular involvement. The degree of hypercoagulability appears to correlate with outcomes…
Goal-directed hemostatic resuscitation of trauma-induced coagulopathy: a pragmatic randomized clinical trial comparing a viscoelastic assay to conventional …
Background: Massive transfusion protocols (MTPs) have become standard of care in the
management of bleeding injured patients, yet strategies to guide them vary widely. We …
management of bleeding injured patients, yet strategies to guide them vary widely. We …
Hyperfibrinolysis, physiologic fibrinolysis, and fibrinolysis shutdown: the spectrum of postinjury fibrinolysis and relevance to antifibrinolytic therapy
BACKGROUND Fibrinolysis is a physiologic process maintaining patency of the microvasculature.
Maladaptive overactivation of this essential function (hyperfibrinolysis) is proposed as …
Maladaptive overactivation of this essential function (hyperfibrinolysis) is proposed as …
Trauma-induced coagulopathy
Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …
Plasma-first resuscitation to treat haemorrhagic shock during emergency ground transportation in an urban area: a randomised trial
Background Plasma is integral to haemostatic resuscitation after injury, but the timing of
administration remains controversial. Anticipating approval of lyophilised plasma by the US …
administration remains controversial. Anticipating approval of lyophilised plasma by the US …
Acute fibrinolysis shutdown after injury occurs frequently and increases mortality: a multicenter evaluation of 2,540 severely injured patients
Background Fibrinolysis is a physiologic process that maintains microvascular patency by
breaking down excessive fibrin clot. Hyperfibrinolysis is associated with a doubling of mortality…
breaking down excessive fibrin clot. Hyperfibrinolysis is associated with a doubling of mortality…
ISTH interim guidance on recognition and management of coagulopathy in COVID‐19: a comment
… Hunter, Dr. Yaffe, and Dr. Moore have patents pending related to both coagulation/fibrinolysis
diagnostics and therapeutic fibrinolytics, and are passive cofounders and holds stock …
diagnostics and therapeutic fibrinolytics, and are passive cofounders and holds stock …
Association of prehospital plasma transfusion with survival in trauma patients with hemorrhagic shock when transport times are longer than 20 minutes: a post hoc …
Importance Both military and civilian clinical practice guidelines include early plasma transfusion
to achieve a plasma to red cell ratio approaching 1:1 to 1:2. However, it was not known …
to achieve a plasma to red cell ratio approaching 1:1 to 1:2. However, it was not known …
Overwhelming tPA release, not PAI-1 degradation, is responsible for hyperfibrinolysis in severely injured trauma patients
BACKGROUND Trauma-induced coagulopathy (TIC) is associated with a fourfold increased
risk of mortality. Hyperfibrinolysis is a component of TIC, but its mechanism is poorly …
risk of mortality. Hyperfibrinolysis is a component of TIC, but its mechanism is poorly …
