Increasingly, human mesenchymal malignancies are being classified by the abnormalities
that drive their pathogenesis. Although many of these aberrations are highly prevalent within …

Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors of the intestinal tract that
typically occur in adults over the age of 40 years. GISTs in younger patients are rare and not …

Patients with neurofibromatosis 1 (NF1) develop multiple neurofibromas, with 8% to 15% of
patients experiencing malignant peripheral nerve sheath tumor (MPNST) during their lifetime…

The newest version of MUMmer easily handles comparisons of large eukaryotic genomes at
varying evolutionary distances, as demonstrated by applications to multiple genomes. Two …

Methods used to sequence the transcriptome often produce more than 200 million short
sequences. We introduce StringTie, a computational method that applies a network flow …

A powerful way to discover key genes with causal roles in oncogenesis is to identify
genomic regions that undergo frequent alteration in human cancers. Here we present high-…

The purpose of this study was to develop a method of classifying cancers to specific diagnostic
categories based on their gene expression signatures using artificial neural networks (…

TGICL is a pipeline for analysis of large Expressed Sequence Tags (EST) and mRNA databases
in which the sequences are first clustered based on pairwise sequence similarity, and …

Background Gastrointestinal stromal tumour is the most common sarcoma of the intestinal
tract. Imatinib mesylate is a small molecule that inhibits activation of the KIT and platelet-…

Background Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal
tumors of the gastrointestinal tract. Neoplastic GIST cells seem to arise from a common …