The functions of, and interactions between, the innate and adaptive immune systems are
vital for anticancer immunity. Cytotoxic T cells expressing cell-surface CD8 are the most …

Background Application of the principles of total mesorectal excision to colon cancer by
undertaking complete mesocolic excision (CME) has been proposed to improve oncological …

Exogenous melatonin has been investigated as treatment for a number of medical and surgical
diseases, demonstrating encouraging results. The aim of this review was to present and …

Purpose The aim of the review was to provide an overview of studies investigating the
pharmacokinetics of exogenous melatonin in humans and if possible, to provide …

Melatonin is an endogenous indoleamine, produced mainly by the pineal gland. Melatonin
has been proven to have chronobiotic, antioxidant, antihypertensive, anxiolytic and sedative …

… Thea Helene Degett, Helene Schou Andersen and Ismail Gögenur all declare that they
have no conflict of interest in this study. This article does not contain any studies with human …

Background The QoR-15 is a patient-reported outcome questionnaire that measures the quality
of recovery after surgery and anaesthesia. We aimed to perform a systematic review and …

Importance Tumour-infiltrating lymphocytes (TILs) have previously been found to influence
patient prognosis in other gastrointestinal cancers, for instance in colorectal cancer. An …

RESEARCH Page 1 Postoperative use of non-steroidal anti-inflammatory drugs in patients
with anastomotic leakage requiring reoperation after colorectal resection: cohort study based …

Importance Colorectal surgery is associated with substantial morbidity rates and a lowered
functional capacity. Optimization of the patient’s condition in the weeks prior to surgery may …