Metformin may exert anti-cancer effects through indirect (insulin-mediated) or direct (insulin-independent)
mechanisms. We report results of a neoadjuvant “window of opportunity” study …

Background The feasibility of video-assisted retroperitoneal debridement (VARD) for infected
pancreatic walled-off necrosis is established. We provide prospective data on the safety …

Background: Regional anesthesia improves postoperative analgesia and enhances quality
of recovery (QoR) after ambulatory surgery. This randomized, double-blinded, parallel-group…

Introduction The antidiabetic drug metformin exhibits potential anticancer properties that are
believed to involve both direct (insulin-independent) and indirect (insulin-dependent) actions…

… Leong, Escallon, Wright and Quan contributed to the conception and design of this article
and the collection of data. Drs. Holloway and McCready contributed to the conception and …

Margin status is one of the most important determinants of local recurrence following breast
conserving surgery. The fact that up to 60% of patients undergoing breast conserving …

Background Intraoperative radiation therapy (IORT) has been investigated for patients with
low-risk, early-stage breast cancer. The The North American experience was evaluated by …

Background and Objectives Serratus fascial plane block can reduce pain following breast
surgery, but the question of whether to inject the local anesthetic superficial or deep to the …

Background Treatment of breast cancer in elderly women is limited by declining functional
status and life expectancy. The impact of providing less aggressive treatment remains …

Background Single-dose intraoperative radiotherapy (IORT) is an emerging treatment for
women with early stage breast cancer. The objective of this study was to define the frequency …