Waveguide sub‐wavelength structures: a review of principles and applications

…, JH Schmid, J Lapointe… - Laser & Photonics …, 2015 - Wiley Online Library
Periodic structures with a sub‐wavelength pitch have been known since Hertz conducted
his first experiments on the polarization of electromagnetic waves. While the use of these …

Taking a “good” look at free radicals in the aging process

S Hekimi, J Lapointe, Y Wen - Trends in cell biology, 2011 - cell.com
The mitochondrial free radical theory of aging (MFRTA) proposes that aging is caused by
damage to macromolecules by mitochondrial reactive oxygen species (ROS). This is based on …

When a theory of aging ages badly

J Lapointe, S Hekimi - Cellular and Molecular Life Sciences, 2010 - Springer
According to the widely acknowledged mitochondrial free radical theory of aging (MFRTA),
the macromolecular damage that results from the production of toxic reactive oxygen species (…

Gene expression profiling identifies clinically relevant subtypes of prostate cancer

J Lapointe, C Li, JP Higgins… - Proceedings of the …, 2004 - National Acad Sciences
Prostate cancer, a leading cause of cancer death, displays a broad range of clinical behavior
from relatively indolent to aggressive metastatic disease. To explore potential molecular …

Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase

…, JP Umland, K Pandher, JM Lapointe… - Proceedings of the …, 2003 - National Acad Sciences
Prostaglandin (PG)E 2 is a potent mediator of pain and inflammation, and high levels of this
lipid mediator are observed in numerous disease states. The inhibition of PGE 2 production …

Nucleosomes inhibit the initiation of transcription but allow chain elongation with the displacement of histones

Y Lorch, JW LaPointe, RD Kornberg - Cell, 1987 - cell.com
Promoters were assembled in nucleosomea or ligated to nucleosomes and transcribed with
SP6 RNA polymeraee or with mammalian RNA polymerase II and accessory factors. Neither …

Computed tomographic diagnosis of intraventricular hemorrhage. Etiology and prognosis.

DA Graeb, WD Robertson, JS Lapointe, RA Nugent… - Radiology, 1982 - pubs.rsna.org
Sixty-eight patients with intraventricular hemorrhage (IVH) diagnosed by computed tomography
(CT) were reviewed retrospectively to determine the etiology and prognosis, relationship …

Refractive index engineering with subwavelength gratings for efficient microphotonic couplers and planar waveguide multiplexers

P Cheben, PJ Bock, JH Schmid, J Lapointe, S Janz… - Optics letters, 2010 - opg.optica.org
We use subwavelength gratings (SWGs) to engineer the refractive index in microphotonic
waveguides, including practical components such as input couplers and multiplexer circuits. …

A silicon-on-insulator photonic wire based evanescent field sensor

…, S Janz, P Cheben, J Lapointe… - IEEE Photonics …, 2006 - ieeexplore.ieee.org
We demonstrate a new, highly sensitive evanescent field sensor using silicon-on-insulator (SOI)
photonic wire waveguides. Theoretical analysis shows that thin SOI waveguides can …

Subwavelength grating periodic structures in silicon-on-insulator: a new type of microphotonic waveguide

PJ Bock, P Cheben, JH Schmid, J Lapointe… - Optics express, 2010 - opg.optica.org
We report on the experimental demonstration and analysis of a new waveguide principle
using subwavelength gratings. Unlike other periodic waveguides such as line-defects in a 2D …