Guidelines for the prevention, detection, and management of surgical site infections (SSI)
have been published previously. 1-3 This document is intended to update earlier guidelines …

Objective: To identify causes and timing of mortality in trauma patients to determine targets
for future studies. Background: In trials conducted by the Resuscitation Outcomes Consortium …

A cornerstone of modern biomedical research is the use of mouse models to explore basic
pathophysiological mechanisms, evaluate new therapeutic approaches, and make go or no-…

Human survival from injury requires an appropriate inflammatory and immune response. We
describe the circulating leukocyte transcriptome after severe trauma and burn injury, as well …

Background Nonoperative management of blunt injury to the spleen in adults has been
applied with increasing frequency. However, the criteria for nonoperative management are …

Background Immunosuppression is a consequence of allogeneic (homologous) blood
transfusion (ABT) in humans and is associated with an increased risk in cancer recurrence rates …

Guidelines regarding the prevention, detection, and management of surgical site infections (SSIs)
have been published previously by a variety of organizations. The American College …

STUDY OBJECTIVE: The first hour after the onset of out-of-hospital traumatic injury is referred
to as the “golden hour,” yet the relationship between time and outcome remains unclear. …

Background Pelvic fractures may be associated with significant hemorrhage. Although this
hemorrhage may emanate from the pelvic vasculature, it may also be secondary to abdominal …

Objective: The detrimental effects of coagulopathy, hypothermia, and acidosis are well
described as markers for mortality after traumatic hemorrhage. Recent military experience …