The application of bioinformatics methodologies to proteins inherently lacking 3D structure
has brought increased attention to these macromolecules. Here topics concerning these …

The nature of cancer control is changing, with an increasing emphasis, fuelled by public and
political demand, on prevention, early diagnosis, and patient experience during and after …

… The connection (loop) between strands i and j of the @-sheet is marked as l;,j or L;,j for
small or large sheet, respectively. The a-helix is referenced as atj, where subscripts refer to the …

We have identified a new protein fold—the α/β hydrolase fold—that is common to several
hydrolytic enzymes of widely differing phylogenetic origin and catalytic function. The core of …

The three-dimensional structure of acetylcholinesterase from Torpedo californica electric
organ has been determined by x-ray analysis to 2.8 angstrom resolution. The form crystallized …

An easy-to-use, versatile and freely available graphic web server, FoldIndex© is described:
it predicts if a given protein sequence is intrinsically unfolded implementing the algorithm of …

The 3-angstrom electron density map of crystalline yeast phenylalanine transfer RNA has
provided us with a complete three-dimensional model which defines the positions of all of the …

Binding sites of Torpedo acetylcholinesterase (EC 3.1.1.7) for quaternary ligands were
investigated by x-ray crystallography and photoaffinity labeling. Crystal structures of complexes …

The Protein Data Bank (PDB) at Brookhaven National Laboratory, is a database containing
experimentally determined three-dimensional structures of proteins, nucleic acids and other …

By rapid hydrolysis of the neurotransmitter, acetylcholine, acetylcholinesterase terminates
neurotransmission at cholinergic synapses. Acetylcholinesterase is a very fast enzyme, …