Wastewater surveillance for pathogens using reverse transcription-polymerase chain reaction
(RT-PCR) is an effective and resource-efficient tool for gathering community-level public …

Mutations in receptor tyrosine kinases (RTKs) have been linked to an increasing number of
inherited human disease syndromes, including dwarfism, craniosynostosis, heritable cancer …

OBJECTIVE: We sought to evaluate a multiplexed massively parallel shotgun sequencing
assay for noninvasive trisomy 21 detection using circulating cell-free fetal DNA. STUDY …

The fibroblast growth factor receptor (FGFR) family members mediate a number of important
cellular processes, and are mutated or overexpressed in several forms of human cancer. …

Objective Whole‐genome sequencing of circulating cell free (ccf) DNA from maternal
plasma has enabled noninvasive prenatal testing for common autosomal aneuploidies. The …

Objective This study introduces a novel method, referred to as SeqFF, for estimating the fetal
DNA fraction in the plasma of pregnant women and to infer the underlying mechanism that …

Cancer is the leading cause of death in dogs, in part because many cases are identified at
an advanced stage when clinical signs have developed, and prognosis is poor. Increased …

BACKGROUND The development of sequencing-based noninvasive prenatal testing (NIPT)
has been largely focused on whole-chromosome aneuploidies (chromosomes 13, 18, 21, X, …

On the 26th of November 2021, the World Health Organization (WHO) designated the newly
detected B.1.1.529 lineage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-…

… Libraries were prepared and quantified as described by Tynan et al. To reduce noise and
increase signal, sequencing depth for this analysis was increased to target 32 million reads …