User profiles for J.T. Rutka
James RutkaHospital for Sick Children, Cell Biology Program, Verified email at sickkids.ca Cited by 46019 |
Nanoparticle-mediated cellular response is size-dependent
Nanostructures of different sizes, shapes and material properties have many applications in
biomedical imaging, clinical diagnostics and therapeutics 1 , 2 , 3 , 4 , 5 , 6 . In spite of what …
biomedical imaging, clinical diagnostics and therapeutics 1 , 2 , 3 , 4 , 5 , 6 . In spite of what …
[HTML][HTML] Medulloblastoma comprises four distinct molecular variants
Purpose Recent genomic approaches have suggested the existence of multiple distinct
subtypes of medulloblastoma. We studied a large cohort of medulloblastomas to determine how …
subtypes of medulloblastoma. We studied a large cohort of medulloblastomas to determine how …
Nanomedicine
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Instagram YouTube LinkedIn Prepare to become a physician, build your knowledge, lead a …
Instagram YouTube LinkedIn Prepare to become a physician, build your knowledge, lead a …
[PDF][PDF] Intertumoral heterogeneity within medulloblastoma subgroups
While molecular subgrouping has revolutionized medulloblastoma classification, the extent
of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to …
of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to …
Mutations in SUFU predispose to medulloblastoma
The sonic hedgehog (SHH) signaling pathway directs the embryonic development of diverse
organisms and is disrupted in a variety of malignancies. Pathway activation is triggered by …
organisms and is disrupted in a variety of malignancies. Pathway activation is triggered by …
[HTML][HTML] Subgroup-specific structural variation across 1,000 medulloblastoma genomes
Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated
with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive …
with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive …
Epigenomic alterations define lethal CIMP-positive ependymomas of infancy
Ependymomas are common childhood brain tumours that occur throughout the nervous
system, but are most common in the paediatric hindbrain. Current standard therapy comprises …
system, but are most common in the paediatric hindbrain. Current standard therapy comprises …
[PDF][PDF] Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma
Despite the histological similarity of ependymomas from throughout the neuroaxis, the
disease likely comprises multiple independent entities, each with a distinct molecular …
disease likely comprises multiple independent entities, each with a distinct molecular …
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma
We used high-resolution SNP genotyping to identify regions of genomic gain and loss in the
genomes of 212 medulloblastomas, malignant pediatric brain tumors. We found focal …
genomes of 212 medulloblastomas, malignant pediatric brain tumors. We found focal …
[PDF][PDF] Change in neurocognitive functioning after treatment with cranial radiation in childhood
Purpose To evaluate the pattern of stability and change over time across multiple domains of
neurocognitive function in radiated survivors of posterior fossa (PF) tumors.
neurocognitive function in radiated survivors of posterior fossa (PF) tumors.