TGFβ signaling regulates epithelial–mesenchymal plasticity in ovarian cancer ascites-derived spheroids

…, YR Valdes, M Bertrand, J McGee… - Endocrine-related …, 2016 - erc.bioscientifica.com
ICB-1 chromosome 1 open reading frame 38 (C1orf38) is a human gene initially described
by our group to be involved in differentiation processes of cancer cells. Recently, we have …

[HTML][HTML] Enhanced recovery after surgery: implementing a new standard of surgical care

AD Altman, L Helpman, J McGee, V Samouëlian… - Cmaj, 2019 - Can Med Assoc
Randomized controlled trials (RCTs), systematic reviews and meta-analyses have shown
that carbohydrate loading before surgery increases insulin sensitivity, reduces postoperative …

[HTML][HTML] Teaching surgery takes time: the impact of surgical education on time in the operating room

C Vinden, R Malthaner, J McGee… - Canadian Journal of …, 2016 - ncbi.nlm.nih.gov
Background It is generally accepted that surgical training is associated with increased surgical
duration. The purpose of this study was to determine the magnitude of this increase for …

Combination of AKT inhibition with autophagy blockade effectively reduces ascites-derived ovarian cancer cell viability

…, TM Peart, EN Fazio, M Bertrand, J McGee… - …, 2014 - academic.oup.com
Recent genomics analysis of the high-grade serous subtype of epithelial ovarian cancer (EOC)
show aberrations in the phosphatidylinositol 3-kinase (PI3K)/AKT pathway that result in …

[HTML][HTML] Intact LKB1 activity is required for survival of dormant ovarian cancer spheroids

…, RJM Correa, E Fazio, M Bertrand, J McGee… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Metastatic epithelial ovarian cancer (EOC) cells can form multicellular spheroids while in
suspension and disperse directly throughout the peritoneum to seed secondary lesions. There …

Risk of breast cancer after a diagnosis of ovarian cancer in BRCA mutation carriers: Is preventive mastectomy warranted?

J McGee, V Giannakeas, B Karlan, J Lubinski… - Gynecologic …, 2017 - Elsevier
Objective Preventive breast surgery and MRI screening are offered to unaffected BRCA
mutation carriers. The clinical benefit of these two modalities has not been evaluated among …

Examining survival outcomes of 852 women with advanced ovarian cancer: a multi-institutional cohort study

T May, A Altman, J McGee, L Lu, W Xu… - International Journal of …, 2018 - ijgc.bmj.com
Introduction This study examines patterns of clinical practice in the management of women
with advanced high-grade serous ovarian carcinoma (HGSC). Methods A total of 852 patients …

Genetics consultation rates following a diagnosis of high-grade serous ovarian carcinoma in the Canadian province of Ontario

J McGee, K Panabaker, S Leonard… - International Journal of …, 2017 - ijgc.bmj.com
Objective In 2001, the province of Ontario expanded cancer genetic testing eligibility to include
all women with high-grade serous ovarian carcinoma (HGSC) of the ovary, fallopian tube, …

Neoadjuvant chemotherapy and chemotherapy cycle number: a national multicentre study

AD Altman, J McGee, T May, K Lane, L Lu, W Xu… - Gynecologic …, 2017 - Elsevier
Objectives Six cycles of consolidation chemotherapy have become the standard for ovarian
cancer treatment regimen following primary cytoreduction, yet with neoadjuvant …

Evaluation of pandemic H1N1 (2009) influenza vaccine in adults with solid tumor and hematological malignancies on active systemic treatment

HJ Mackay, J McGee, D Villa, JB Gubbay… - Journal of Clinical …, 2011 - Elsevier
BACKGROUND: Over 85% of healthy individuals vaccinated with the pandemic H1N1 (pH1N1)
vaccine achieve seroprotection. OBJECTIVES: We evaluated the safety and …