Purpose Recent genomic approaches have suggested the existence of multiple distinct
subtypes of medulloblastoma. We studied a large cohort of medulloblastomas to determine how …

While molecular subgrouping has revolutionized medulloblastoma classification, the extent
of heterogeneity within subgroups is unknown. Similarity network fusion (SNF) applied to …

The sonic hedgehog (SHH) signaling pathway directs the embryonic development of diverse
organisms and is disrupted in a variety of malignancies. Pathway activation is triggered by …

Purpose: High‐frequency oscillations (HFOs), termed ripples at 80–200 Hz and fast ripples (FRs)
at >200/250 Hz, recorded by intracranial electroencephalography (EEG), may be a …

Nanostructures of different sizes, shapes and material properties have many applications in
biomedical imaging, clinical diagnostics and therapeutics 1 , 2 , 3 , 4 , 5 , 6 . In spite of what …

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Medulloblastoma, the most common malignant paediatric brain tumour, is currently treated
with nonspecific cytotoxic therapies including surgery, whole-brain radiation, and aggressive …

Despite the histological similarity of ependymomas from throughout the neuroaxis, the
disease likely comprises multiple independent entities, each with a distinct molecular …

✓ The extracellular matrix (ECM) is the naturally occurring substrate upon which cells migrate,
proliferate, and differentiate. The ECM functions as a biological adhesive that maintains …

We used high-resolution SNP genotyping to identify regions of genomic gain and loss in the
genomes of 212 medulloblastomas, malignant pediatric brain tumors. We found focal …