Background There is convincing preclinical evidence that early decompression in the setting
of spinal cord injury (SCI) improves neurologic outcomes. However, the effect of early …

Degenerative cervical myelopathy (DCM) is the leading cause of spinal cord dysfunction in
adults worldwide. DCM encompasses various acquired (age-related) and congenital …

… Other tools, such as that developed by Wilson et al. , use age, neurological examination and
MRI features and can accurately predict the likelihood of long-term functional independence…

BACKGROUND: Traumatic spinal cord injuries (SCI) have devastating consequences for
the physical, financial, and psychosocial well-being of patients and their caregivers. …

Background: Cervical spondylotic myelopathy is the leading cause of spinal cord
dysfunction worldwide. The objective of this study was to evaluate the impact of surgical …

Background Although there is a strong biological rationale for early decompression of the
injured spinal cord, the influence of the timing of surgical decompression for acute spinal cord …

Study Design: Guideline development. Objectives: The objective of this study is to develop
guidelines that outline how to best manage (1) patients with mild, moderate, and severe …

Acute spinal cord injury (SCI) is a traumatic event that results in disturbances to normal
sensory, motor, or autonomic function and ultimately affects a patient’s physical, psychological, …

A prospective, multicenter phase I trial was undertaken by the North American Clinical Trials
Network (NACTN) to investigate the pharmacokinetics and safety of, as well as obtain pilot …

• Intravenous methylprednisolone has been used as a neuroprotective strategy based on
limited evidence, but this is not a standard of care and may be associated with an increased …