User profiles for John E. Dick
John E. DickUniversity of Toronto Verified email at uhnresearch.ca Cited by 78872 |
Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
In acute myeloid leukaemia (AML), the cell of origin, nature and biological consequences of
initiating lesions, and order of subsequent mutations remain poorly understood, as AML is …
initiating lesions, and order of subsequent mutations remain poorly understood, as AML is …
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell
On the subject of acute myeloid leukemia (AML), there is little consensus about the target cell
within the hematopoietic stem cell hierarchy that is susceptible to leukemic transformation, …
within the hematopoietic stem cell hierarchy that is susceptible to leukemic transformation, …
A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
CA O'Brien, A Pollett, S Gallinger, JE Dick - Nature, 2007 - nature.com
Colon cancer is one of the best-understood neoplasms from a genetic perspective 1 , 2 , 3 ,
yet it remains the second most common cause of cancer-related death, indicating that some …
yet it remains the second most common cause of cancer-related death, indicating that some …
[HTML][HTML] The genetic basis of early T-cell precursor acute lymphoblastic leukaemia
Early T-cell precursor acute lymphoblastic leukaemia (ETP ALL) is an aggressive malignancy
of unknown genetic basis. We performed whole-genome sequencing of 12 ETP ALL cases …
of unknown genetic basis. We performed whole-genome sequencing of 12 ETP ALL cases …
[PDF][PDF] Evolution of the cancer stem cell model
Genetic analyses have shaped much of our understanding of cancer. However, it is becoming
increasingly clear that cancer cells display features of normal tissue organization, where …
increasingly clear that cancer cells display features of normal tissue organization, where …
A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
…, M Minden, B Paterson, MA Caligiuri, JE Dick - nature, 1994 - nature.com
MOST human acute myeloid leukaemia (AML) cells have limited proliferative capacity,
suggesting that the leukaemic clone may be maintained by a rare population of stem cells 1–5 . …
suggesting that the leukaemic clone may be maintained by a rare population of stem cells 1–5 . …
Cancer stem cells—perspectives on current status and future directions: AACR Workshop on cancer stem cells
A workshop was convened by the AACR to discuss the rapidly emerging cancer stem cell
model for tumor development and progression. The meeting participants were charged with …
model for tumor development and progression. The meeting participants were charged with …
Targeting of CD44 eradicates human acute myeloid leukemic stem cells
The long-term survival of patients with acute myeloid leukemia (AML) is dismally poor. A
permanent cure of AML requires elimination of leukemic stem cells (LSCs), the only cell type …
permanent cure of AML requires elimination of leukemic stem cells (LSCs), the only cell type …
Stem cell concepts renew cancer research
JE Dick - Blood, The Journal of the American Society of …, 2008 - ashpublications.org
Although uncontrolled proliferation is a distinguishing property of a tumor as a whole, the
individual cells that make up the tumor exhibit considerable variation in many properties, …
individual cells that make up the tumor exhibit considerable variation in many properties, …
Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity
Emerging evidence suggests cancer stem cells sustain neoplasms; however, little is understood
of the normal cell initially targeted and the resultant cancer stem cells. We show here, by …
of the normal cell initially targeted and the resultant cancer stem cells. We show here, by …