Metastatic cancer remains an incurable disease in the majority of cases and thus novel
treatment strategies such as oncolytic virotherapy are rapidly advancing toward clinical use. In …

Blood supply within a tumor drives progression and ultimately allows for metastasis. Many
anticancer therapies target tumor vasculature, but their individual effectiveness is limited …

Oncolytic viruses designed to attack malignant cells can in addition infect and destroy tumor
vascular endothelial cells. We show here that this expanded tropism of oncolytic vaccinia …

Clinical wound assessment involves microbiological swabbing of wounds to identify and
quantify bacterial species, and to determine microbial susceptibility to antibiotics. The Levine …

Oncolytic vaccinia viruses have shown compelling results in preclinical cancer models and
promising preliminary safety and antitumor activity in early clinical trials. However, to facilitate …

Metastatic colorectal cancer (CRC) is complex clinical challenge for which there are limited
treatment options. Chemotherapy with or without surgery provides moderate improvements …

Tumor-specific overexpression of receptors enables a variety of targeted cancer therapies,
exemplified by peptide-receptor radiotherapy (PRRT) for somatostatin receptor (SSTR)-…

Background Re-excision due to positive margins following breast-conserving surgery (BCS)
negatively affects patient outcomes and healthcare costs. The inability to visualize margin …

Tumor vascularization is critical for oncolytic vaccinia virus treatment of peritoneal
carcinomatosis - Ottolino‐Perry - 2014 - International Journal of Cancer - Wiley Online Library …

… The dissociation constant (K d ) and the maximum binding sites per cell (B max ) were …
Kathryn Ottolino-Perry is the recipient of a predoctoral fellowship from the CIHR Strategic Training …