Approximately five decades ago, alloimmunization to human leukocyte antigens (HLA) and
platelet refractoriness were recognized as potentially serious complications of platelet …

Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is a potentially fatal thrombotic
microangiopathy caused by autoantibody-mediated severe deficiency of ADAMTS13. …

Background About 5% of civilian trauma requires massive transfusion. Protocolized resuscitation
with blood products to achieve high plasma:RBC ratio has been advocated to improve …

Background In acquired thrombotic thrombocytopenic purpura (TTP), an immune-mediated
deficiency of the von Willebrand factor–cleaving protease ADAMTS13 allows unrestrained …

Importance Blood transfusion is one of the most frequently used therapies worldwide and is
associated with benefits, risks, and costs. Objective To develop a set of evidence-based …

… K. Pavenski reports receiving honoraria from Alexion Inc., outside the submitted work. B.
Lämmle reports receiving grants from Baxter Biosciences and personal fees from Baxalta, …

Importance Excessive bleeding is a common complication of cardiac surgery. An important
cause of bleeding is acquired hypofibrinogenemia (fibrinogen level <1.5-2.0 g/L), for which …

Importance Red blood cell transfusion is a common medical intervention with benefits and
harms. Objective To provide recommendations for use of red blood cell transfusion in adults …

… Slichter b , Susano Tanael c , Paolo Rebulla d , Katerina Pavenski e , Ralph Vassallo f , Mark
Fung g , Rene Duquesnoy h , … HLA-selected platelet transfusion Pavenski et al [24] 1 29 …

Novel oral anticoagulants (NOACs)(rivaroxaban, dabigatran, apixaban) have been approved
by international regulatory agencies to treat atrial fibrillation and venous thromboembolism …