Context Between March and July 2009, the largest number of confirmed cases of 2009
influenza A(H1N1) infection occurred in North America. Objective To describe characteristics, …

Objective: To determine if beta-(β)-blockers improve outcomes after acute traumatic brain
injury (TBI). Background: There have been no new inpatient pharmacologic therapies to …

BACKGROUND The management of penetrating colon injuries in civilians has evolved over
the last four decades. The objectives of this meta-analysis are to evaluate the current …

Background Elevated proinflammatory cytokines are associated with greater COVID-19 severity.
We aimed to assess safety and efficacy of sarilumab, an interleukin-6 receptor inhibitor, …

BACKGROUND Within the GRADE (Grading of Recommendations Assessment, Development
and Evaluation) framework, we performed a systematic review and developed evidence-…

Background Guidelines recommend the use of bioprosthetics for abdominal wall reinforcement
in contaminated fields, but the evidence supporting the use of biologic over synthetic non-…

Background: Injury to the cervical spine (CS) is common after major trauma. The Eastern
Association for the Surgery of Trauma first published its Practice Management Guidelines for …

Background: The role of remdesivir in the treatment of patients in hospital with COVID-19
remains ill defined in a global context. The World Health Organization Solidarity randomized …

Importance Growing interest in microbial dysbiosis during critical illness has raised
questions about the therapeutic potential of microbiome modification with probiotics. Prior …

Background: With an increasing life expectancy and more active elderly population,
management of geriatric trauma patients continues to evolve. The aim was to describe the …