IBM experiments in soft fails in computer electronics (1978–1994)
…, LB Freeman, P Hosier, LE LaFave… - IBM journal of …, 1996 - ieeexplore.ieee.org
… Most devices, prior to the 64Kb RAM devices, had such large Q^^t values that fail rates
were less than l/Mhr, and hence negligible. But the new 64Kb RAMs had about six times …
were less than l/Mhr, and hence negligible. But the new 64Kb RAMs had about six times …
[HTML][HTML] Chromatin potential identified by shared single-cell profiling of RNA and chromatin
Cell differentiation and function are regulated across multiple layers of gene regulation,
including modulation of gene expression by changes in chromatin accessibility. However, …
including modulation of gene expression by changes in chromatin accessibility. However, …
JAK2 the future: therapeutic strategies for JAK-dependent malignancies
LM LaFave, RL Levine - Trends in pharmacological sciences, 2012 - cell.com
The Janus kinase (JAK) proteins are a family of intracellular nonreceptor tyrosine kinases
involved in cytokine signaling via the JAK–STAT (signal transducers and activators of …
involved in cytokine signaling via the JAK–STAT (signal transducers and activators of …
[HTML][HTML] Impact of COVID-19 on early childhood educator's perspectives and practices in nutrition and physical activity: A qualitative study
L Lafave, AD Webster, C McConnell - Early Childhood Education Journal, 2021 - Springer
Government guidelines for relaunching early childhood education and care (ECEC) programs
during the COVID-19 pandemic have required the implementation of various practices to …
during the COVID-19 pandemic have required the implementation of various practices to …
[PDF][PDF] ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression
Recurrent somatic ASXL1 mutations occur in patients with myelodysplastic syndrome,
myeloproliferative neoplasms, and acute myeloid leukemia, and are associated with adverse …
myeloproliferative neoplasms, and acute myeloid leukemia, and are associated with adverse …
Loss of the tumor suppressor BAP1 causes myeloid transformation
…, CE Bakalarski, J Wu, L Phu, P Katavolos, LM LaFave… - Science, 2012 - science.org
De-ubiquitinating enzyme BAP1 is mutated in a hereditary cancer syndrome with increased
risk of mesothelioma and uveal melanoma. Somatic BAP1 mutations occur in various …
risk of mesothelioma and uveal melanoma. Somatic BAP1 mutations occur in various …
Loss of BAP1 function leads to EZH2-dependent transformation
The tumor suppressors BAP1 and ASXL1 interact to form a polycomb deubiquitinase complex
that removes monoubiquitin from histone H2A lysine 119 (H2AK119Ub). However, BAP1 …
that removes monoubiquitin from histone H2A lysine 119 (H2AK119Ub). However, BAP1 …
Spatial genomics enables multi-modal study of clonal heterogeneity in tissues
The state and behaviour of a cell can be influenced by both genetic and environmental factors.
In particular, tumour progression is determined by underlying genetic aberrations 1 , 2 , 3 …
In particular, tumour progression is determined by underlying genetic aberrations 1 , 2 , 3 …
Deletion of Asxl1 results in myelodysplasia and severe developmental defects in vivo
…, T Hricik, D Ndiaye-Lobry, LM LaFave… - Journal of Experimental …, 2013 - rupress.org
Somatic Addition of Sex Combs Like 1 (ASXL1) mutations occur in 10–30% of patients with
myeloid malignancies, most commonly in myelodysplastic syndromes (MDSs), and are …
myeloid malignancies, most commonly in myelodysplastic syndromes (MDSs), and are …
[PDF][PDF] Epigenomic state transitions characterize tumor progression in mouse lung adenocarcinoma
Regulatory networks that maintain functional, differentiated cell states are often dysregulated
in tumor development. Here, we use single-cell epigenomics to profile chromatin state …
in tumor development. Here, we use single-cell epigenomics to profile chromatin state …