User profiles for L.A. MacLaren

Leslie MacLaren

Professor, Animal Physiology, Dalhousie University
Verified email at dal.ca
Cited by 1710

Effect of interferon-τ on prostaglandin biosynthesis, transport, and signaling at the time of maternal recognition of pregnancy in cattle: evidence of polycrine actions of …

…, S Kimmins, P Chapdelaine, LA Maclaren… - …, 2004 - academic.oup.com
Recognition and establishment of pregnancy involve several molecular and cellular interactions
among the conceptus, uterus, and corpus luteum (CL). In ruminants, interferon-τ (IFNτ) …

Oestrous cycle and pregnancy effects on the distribution of oestrogen and progesterone receptors in bovine endometrium

S Kimmins, LA MacLaren - Placenta, 2001 - Elsevier
Reproductive cyclicity and pregnancy require cell and tissue specific expression of oestrogen
(OR) and progesterone receptors (PR). To determine the effects of cycle day and early …

Implantation-associated changes in bovine uterine expression of integrins and extracellular matrix

…, S Kimmins, JA Small, LA MacLaren - Biology of …, 2002 - academic.oup.com
Appropriate integrin expression appears to be necessary for successful implantation of human
embryos and varies considerably among species. The present study was undertaken to …

Derivation and validation of the Denver Human Immunodeficiency Virus (HIV) risk score for targeted HIV screening

…, RE Rothman, YH Hsieh, LA MacLaren… - American journal of …, 2012 - academic.oup.com
Targeted screening remains an important approach to human immunodeficiency virus (HIV)
testing. The authors aimed to derive and validate an instrument to accurately identify …

Molecular Cloning and Characterization of Bovine Prostaglandin E2 Receptors EP2 and EP4: Expression and Regulation in Endometrium and Myometrium during …

…, P Chapdelaine, V Emond, JJ Kim, LA MacLaren… - …, 2003 - academic.oup.com
Prostaglandins (PGs) play important functions in the reproductive system, and PGE 2 appears
necessary for recognition of pregnancy. We have found that PGE 2 is able to increase …

Expression of cyclooxygenase-2 and granulocyte-macrophage colony-stimulating factor in the endometrial epithelium of the cow is up-regulated during early …

V Emond, LA MacLaren, S Kimmins… - Biology of …, 2004 - academic.oup.com
On the basis of results obtained in vitro, we previously proposed a model in which signals
from the conceptus, namely interferon-tau (IFN-τ) and prostaglandin E 2 , increase the …

Peroxisome proliferator-activated receptor (PPAR) expression in cultured bovine endometrial cells and response to omega-3 fatty acid, growth hormone and agonist …

LA MacLaren, A Guzeloglu, F Michel… - Domestic Animal …, 2006 - Elsevier
The peroxisome proliferator-activated receptors (PPARs) are a family of nuclear transcription
factors thought to act as receptors for polyunsaturated fatty acids and to reduce production …

[HTML][HTML] Pregnancy, bovine somatotropin, and dietary n-3 fatty acids in lactating dairy cows: II. Endometrial gene expression related to maintenance of pregnancy

TR Bilby, A Guzeloglu, LA MacLaren, CR Staples… - Journal of dairy …, 2006 - Elsevier
The objectives were to examine the effects of bovine somatotropin (bST), pregnancy, and
dietary fatty acids on expression of key endometrial genes and proteins regulating …

[HTML][HTML] Effects of dietary inclusion of seaweed, heat stress and genetic strain on performance, plasma biochemical and hematological parameters in laying hens

…, BM Rathgeber, CM Stupart, J MacIsaac, LA MacLaren - Animals, 2020 - mdpi.com
Simple Summary Prebiotics such as seaweeds have been proposed as positive influencers
on hen health and productivity, including their response to stressors such as heat. The …

Estrogen selectively up-regulates the phospholipid hydroperoxide glutathione peroxidase in the oviducts

J Lapointe, S Kimmins, LA MacLaren… - Endocrinology, 2005 - academic.oup.com
The oviduct plays a crucial role in mammalian reproduction by providing an optimal
environment for the final maturation and transport of gametes, fertilization, and early embryonic …