BACKGROUND: Inflammatory bowel disease (IBD) is associated with increased intestinal
permeability and decreased expression of tight junction (TJ) proteins in the inflamed mucosa. …

Preclinical human IBD mechanisms is part of five focus areas of the Challenges in IBD
research document, which also include environmental triggers, novel technologies, precision …

BACKGROUND: Early readmission after discharge from the hospital is an undesirable
outcome. Ileostomies are commonly used to prevent symptomatic anastomotic complications in …

Background and Aims Studies have shown a decrease in key tight junction (TJ) proteins such
as ZO-1 and occludin in both inflammatory bowel disease (IBD) and experimental models …

PURPOSE: Tumor necrosis factor antagonist therapy in the form of infliximab has been
shown to promote significant healing in fistulizing Crohn’s disease and therefore is often …

Lin Z, Hegarty JP, Cappel JA, Yu W, Chen X, Faber P, Wang Y, Kelly AA, Poritz LS, Peterson
BZ, Schreiber S, Fan J‐B, Koltun WA. Identification of disease‐associated DNA methylation …

BACKGROUND: We have previously shown an increase in intestinal permeability and a
corresponding decrease in the expression of tight junction (TJ) proteins in the in testines of …

BACKGROUND:: Surgical site infections (SSIs) are a well known complication of
gastrointestinal surgery and associated with an increased morbidity, mortality and overall cost. …

Objective: To determine if single nuclear polymorphisms (SNPs) in the TFNSF15 gene play
a role in patients requiring surgery for diverticulitis. Background: A role for a genetic …

PURPOSE: Ileal pouch-anal anastomosis continues to be confounded by Crohn's disease-like
complications after surgery. Such patients experience significant morbidity and often …