Chronic pain is associated with reduced brain gray matter and impaired cognitive ability. In
this longitudinal study, we assessed whether neuroanatomical and functional abnormalities …

Agonists acting at α 2 adrenergic and opioid receptors have analgesic properties and act
synergistically when co-administered in the spinal cord; this synergy may also contribute to the …

Antagonists of glutamate receptors of the N-methyl-d-aspartate subclass (NMDAR) or
inhibitors of nitric oxide synthase (NOS) prevent nervous system plasticity. Inflammatory and …

α 2 -Adrenergic receptors (α 2 -ARs) mediate a number of physiological phenomena, including
spinal analgesia. We have developed subtype-selective antisera against the C termini of …

The α 2A -adrenergic receptor (AR) subtype mediates antinociception induced by the α 2
AR agonists clonidine, dexmedetomidine, norepinephrine, and 5-bromo-N-(4,5-dihydro-1H-…

Introduction Excessive mechanical loading of intervertebral discs (IVDs) is thought to alter
matrix properties and influence disc cell metabolism, contributing to degenerative disc disease …

Intervertebral disc degeneration ( IVD ) can result in chronic low back pain, a common
cause of morbidity and disability. Inflammation has been associated with IVD degeneration, …

We previously reported that effective treatment of chronic low back pain (CLBP) reversed
abnormal brain structure and functional MRI (fMRI) activity during cognitive task performance, …

Changes in brain structure and cortical function are associated with many chronic pain
conditions including low back pain and fibromyalgia. The magnitude of these changes correlates …

OBJECTIVE: To determine the test characteristics of a self-report questionnaire, the Beck
Depression Inventory, when used as a screening test for depression in a population of …