Growing evidence has demonstrated that clonogenic cancer stem (initiating) cells are
responsible for tumor regrowth and disease relapse. Bmi‐1 plays a critical role in the self‐renewal …

Tumor recurrence following treatment remains a major clinical challenge. Evidence from
xenograft models and human trials indicates selective enrichment of cancer-initiating cells (CICs…

The coronavirus disease 2019 (COVID-19) pandemic has created an urgent need for
therapeutics that inhibit the SARS−COV-2 virus and suppress the fulminant inflammation …

PTC299 was identified as an inhibitor of VEGFA mRNA translation in a phenotypic screen
and evaluated in the clinic for treatment of solid tumors. To guide precision cancer treatment, …

Purpose: Current prostate cancer management calls for identifying novel and more effective
therapies. Self-renewing tumor-initiating cells (TICs) hold intrinsic therapy resistance and …

Lung cancer is the most common cause of cancer deaths. The expression of the transcription
factor C/EBPα (CCAAT/enhancer binding protein α) is frequently lost in non–small cell lung …

BMI-1, also known as a stem cell factor, is frequently upregulated in several malignancies.
Elevated expression of BMI-1 correlates with poor prognosis and is therefore considered a …

… Liangxian Cao … Liangxian Cao … Baird, Liangxian Cao, Mandar Dali, Bansri Furia, Min
Jung Kim, Kylie O'Keefe, Ronald Kong, Oscar L. Laskin, Joseph M. Colacino, Mark Pykett, Anna …

Purpose: Pancreatic ductal adenocarcinoma (PDA) is a deadly cancer that is broadly
chemoresistant, due in part to biophysical properties of tumor stroma, which serves as a barrier to …

Medulloblastoma (MB) is the most frequent malignant pediatric brain tumor, representing 20%
of newly diagnosed childhood central nervous system malignancies. Although advances …