Deterioration after surgery for degenerative cervical myelopathy: an observational study from the canadian spine outcomes and research network
Study Design. A Prospective cohort study. Objective. To investigate the incidence, etiology,
and outcomes of patients who experience neurological deterioration after surgery for …
and outcomes of patients who experience neurological deterioration after surgery for …
Analysis of intronic and exonic reads in RNA-seq data characterizes transcriptional and post-transcriptional regulation
RNA-seq experiments generate reads derived not only from mature RNA transcripts but
also from pre-mRNA. Here we present a computational approach called exon-intron split …
also from pre-mRNA. Here we present a computational approach called exon-intron split …
[HTML][HTML] Transcription factor occupancy can mediate active turnover of DNA methylation at regulatory regions
Distal regulatory elements, including enhancers, play a critical role in regulating gene activity.
Transcription factor binding to these elements correlates with Low Methylated Regions (…
Transcription factor binding to these elements correlates with Low Methylated Regions (…
BANP opens chromatin and activates CpG-island-regulated genes
The majority of gene transcripts generated by RNA polymerase II in mammalian genomes
initiate at CpG island (CGI) promoters 1 , 2 , yet our understanding of their regulation remains …
initiate at CpG island (CGI) promoters 1 , 2 , yet our understanding of their regulation remains …
[PDF][PDF] Pioneering activity of the C-terminal domain of EBF1 shapes the chromatin landscape for B cell programming
… d CTD enables EBF1 to access progenitor chromatin at sites with low TF co-occupancy …
(D) Quantification of EBF1 level after cycloheximide treatment in EBF1wt- or EBF1DC-transduced …
(D) Quantification of EBF1 level after cycloheximide treatment in EBF1wt- or EBF1DC-transduced …
Competition between DNA methylation and transcription factors determines binding of NRF1
…, P Adrian Ginno, D Hartl, L Burger, D Schübeler - Nature, 2015 - nature.com
Eukaryotic transcription factors (TFs) are key determinants of gene activity, yet they bind only
a fraction of their corresponding DNA sequence motifs in any given cell type 1 . Chromatin …
a fraction of their corresponding DNA sequence motifs in any given cell type 1 . Chromatin …
CG dinucleotides enhance promoter activity independent of DNA methylation
Most mammalian RNA polymerase II initiation events occur at CpG islands, which are rich in
CpGs and devoid of DNA methylation. Despite their relevance for gene regulation, it is …
CpGs and devoid of DNA methylation. Despite their relevance for gene regulation, it is …
[HTML][HTML] Dynamic DNA methylation orchestrates cardiomyocyte development, maturation and disease
… (c,d) DNA methylation traces of troponin I genes Tnni1 (c) and Tnni3 (d) in ES cells,
newborn and adult cardiomyocytes (upper panels). Time course of genic DNA methylation (left …
newborn and adult cardiomyocytes (upper panels). Time course of genic DNA methylation (left …
DNA-binding factors shape the mouse methylome at distal regulatory regions
Methylation of cytosines is an essential epigenetic modification in mammalian genomes, yet
the rules that govern methylation patterns remain largely elusive. To gain insights into this …
the rules that govern methylation patterns remain largely elusive. To gain insights into this …
DNA methylation is required for the control of stem cell differentiation in the small intestine
…, EN Elliott, J Schug, L Burger, D Schübeler… - Genes & …, 2014 - genesdev.cshlp.org
The mammalian intestinal epithelium has a unique organization in which crypts harboring
stem cells produce progenitors and finally clonal populations of differentiated cells. …
stem cells produce progenitors and finally clonal populations of differentiated cells. …
