Purpose The shortage of organs for transplantation is an important medical and societal
problem because transplantation is often the best therapeutic option for end-stage organ failure. …

This review outlines the new and promising technique of ex vivo lung perfusion and its clinical
potential to increase the number of transplantable lungs and to improve the early and late …

Extracorporeal life support (ECLS) is an artificial means of maintaining adequate oxygenation
and carbon dioxide elimination to enable injured lungs to recover from underlying disease…

Background More than 80% of donor lungs are potentially injured and therefore not considered
suitable for transplantation. With the use of normothermic ex vivo lung perfusion (EVLP), …

Tens of thousands of patients with advanced lung diseases may be eligible to be considered
as potential candidates for lung transplant around the world each year. The timing of referral…

BACKGROUND: The inhibition of cellular metabolism induced by hypothermia obviates the
possibility of substantial reparative processes occurring during organ preservation. The aim …

Background Few resources are available to support caregivers of patients who have survived
critical illness; consequently, the caregivers’ own health may suffer. We studied caregiver …

Rationale: Disability risk groups and 1-year outcome after greater than or equal to 7 days of
mechanical ventilation (MV) in medical/surgical intensive care unit (ICU) patients are …

Treatment of injured donor lungs ex vivo to accelerate organ recovery and ameliorate
reperfusion injury could have a major impact in lung transplantation. We have recently …

More than 80% of potential donor lungs are injured during brain death of the donor and
from complications experienced in the intensive care unit, and therefore cannot be used for …