We submit that the safe operating space of the planetary boundary of novel entities is exceeded
since annual production and releases are increasing at a pace that outstrips the global …

… The review article entitled ‘The global threat from plastic pollution by Macleod and co-authors
highlighted the problems associated with the increasing accumulation of plastic pollution …

Each year vast amounts of plastic are produced worldwide. When released to the
environment, plastics accumulate, and plastic debris in the world's oceans is of particular …

Background Concerns regarding potential neurological complications of COVID-19 are being
increasingly reported, primarily in small series. Larger studies have been limited by both …

Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal
Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve the …

Nitrous oxide (N 2 O), like carbon dioxide, is a long-lived greenhouse gas that accumulates
in the atmosphere. Over the past 150 years, increasing atmospheric N 2 O concentrations …

Background, aim and scope In 2005, a comprehensive comparison of life cycle impact
assessment toxicity characterisation models was initiated by the United Nations Environment …

Improving the reproducibility of biomedical research is a major challenge. Transparent and
accurate reporting is vital to this process; it allows readers to assess the reliability of the …

Correctable weaknesses in the design, conduct, and analysis of biomedical and public
health research studies can produce misleading results and waste valuable resources. Small …

Objective Preclinical evaluation of neuroprotectants fostered high expectations of clinical
efficacy. When not matched, the question arises whether experiments are poor indicators of …