Importance Progression-free survival (PFS) has become a commonly used outcome to assess
the efficacy of new cancer drugs. However, it is not clear if delay in progression leads to …

Marko Curkovic in his letter (2017) points out that using Google Search in our systematic
review (Piasecki et al. 2017) could have led to the so-called “bubble effect”, a form of selection …

Our objective was to summarise systematically all research evidence related to how
patients value outcomes in chronic obstructive pulmonary disease (COPD). We conducted a …

Objectives : The aim of this research was to evaluate right ventricular pacing effects on left
ventricular function. Background : Right ventricular pacing alters the ventricular activation …

Background Conducting research during or in the aftermath of disasters poses many specific
practical and ethical challenges. This is particularly the case with research involving human …

Current knowledge of pulmonary arterial hypertension (PAH) epidemiology is based mainly
on data from Western populations, and therefore we aimed to characterize a large group of …

… Our patients had higher body mass index (27.4±5.3 vs 22.3±3.4 kg/m 2 ) than the Japanese
patient population25 and presented a significant number of conditions predisposing for …

… The mean 6MWD was 334 ± 166.4 m, the mean NT-proBNP level was 1482 ± 3130 pg/ml, …
Marcin Waligóra has nothing to declare. Marek Roik has nothing to declare. Marek Grabka …

Background Assent is an important ethical and legal requirement of paediatric research.
Unfortunately, there are significant differences between the guidelines on the details of assent. …

Background Novel precision oncology trial designs, such as basket and umbrella trials, are
designed to test new anticancer agents in more effective and affordable ways. However, they …