[PDF][PDF] The structure of docking domains in modular polyketide synthases

RW Broadhurst, D Nietlispach, MP Wheatcroft… - Chemistry & biology, 2003 - cell.com
… glycerol, 1 mM DTT, 1 mM EDTA, pH adjusted with imidazole to 6.8; buffer B: as A, but with 1
M NaCl). … M. Moncrieffe for advice and assistance, and Professor J. Staunton FRS for helpful …

[PDF][PDF] Increasing the efficiency of heterologous promoters in actinomycetes

…, T Mironenko, M Deacon, M Wheatcroft… - Journal of molecular …, 2002 - caister.com
An Escherichia coli–actinomycete shuttle vector, pCJW93, was constructed which places
cloned genes under the control of the thiostrepton-inducible tip promoter from Streptomyces …

Diabody pretargeting with click chemistry in vivo

…, SM van den Bosch, MP Wheatcroft… - Journal of Nuclear …, 2015 - Soc Nuclear Med
Radioimmunotherapy and nuclear imaging (immuno-PET/SPECT) of cancer with radiometal-labeled
antibody fragments or peptides is hampered by low tumor-to-kidney ratios because …

Increased in-stent stenosis in ApoE knockout mice: insights from a novel mouse model of balloon angioplasty and stenting

…, T Bannister, Y Hu, S Mussa, M Wheatcroft… - … , and vascular biology, 2007 - Am Heart Assoc
Objective— We aimed to develop and validate a model of angioplasty and stenting in mice
that would allow investigation of the response to stent injury using genetically modified …

The economic burden of inpatient diabetic foot ulcers in Toronto, Canada

…, A Zamzam, C de Mestral, M Wheatcroft… - …, 2020 - journals.sagepub.com
Objective Diabetic foot ulcer, which often leads to lower limb amputation, is a devastating
complication of diabetes that is a major burden on patients and the healthcare system. The …

[HTML][HTML] First clinical study of a pegylated diabody 124I-labeled PEG-AVP0458 in patients with tumor-associated glycoprotein 72 positive cancers

…, SJ Gong, JS Pedersen, FE Scott, MP Wheatcroft… - Theranostics, 2020 - ncbi.nlm.nih.gov
… The choice of the two doses of PEG-AVP0458, 1 mg/m 2 and 10 mg/m 2 , was based on our
… occurred at 10 mg/m 2 dose levels 24 - 26 . We also established 1.0 mg/m 2 as a suitable …

[HTML][HTML] Autophagy gene fingerprint in human ischemia and reperfusion

…, A Garg, R Khan, Y Pan, MD Wheatcroft… - The Journal of thoracic …, 2014 - Elsevier
Objective Autophagy is an evolutionary conserved adaptive response that is believed to
promote cell survival in response to stressful stimuli via recycling of precursors derived from the …

Site-specific conjugation of monodispersed DOTA-PEGn to a thiolated diabody reveals the effect of increasing peg size on kidney clearance and tumor uptake with …

…, J Carmichael, D Leong, MP Wheatcroft… - Bioconjugate …, 2011 - ACS Publications
… two minor peaks, the major one (m/z = 26822) corresponding to the expected mass including
the His6 C-terminal tag and a minor peak at m/z = 25,999 corresponding to the expected …

Does pleurotomy during internal mammary artery harvest increase post-operative pulmonary complications?

M Wheatcroft, V Shrivastava, B Nyawo… - Interactive …, 2005 - academic.oup.com
A best evidence topic in cardiac surgery was written according to a structured protocol. The
question addressed was whether pleurotomy during internal mammary artery (IMA) harvest …

[HTML][HTML] Carbonic Anhydrase IX-Targeted α-Radionuclide Therapy with 225Ac Inhibits Tumor Growth in a Renal Cell Carcinoma Model

…, F Bruchertseifer, E Yan, MP Wheatcroft… - Pharmaceuticals, 2022 - mdpi.com
In this study, we compared the tumor-targeting properties, therapeutic efficacy, and tolerability
of the humanized anti-CAIX antibody (hG250) labeled with either the α-emitter actinium-…