The delivery of many potentially therapeutic and diagnostic compounds to specific areas of
the brain is restricted by brain barriers, of which the most well known are the blood–brain …

Women are at higher risk throughout their reproductive lives than are men for major depression.
Numerous molecular and clinical studies have implicated estrogen in modulating brain …

… Owing to financial and technical constraints, we were unable to obtain melatonin levels
or urine metabolite estimations. This was a major problem in our studies. Nevertheless, the …

DNA-damaging agents are among the most frequently used anticancer drugs. However,
they provide only modest benefit in most cancers. This may be attributed to a genome …

Increased transport of Na + across an intact blood-brain barrier (BBB) participates in edema
formation during the early hours of cerebral ischemia. In previous studies, the authors …

Eukaryotes use distinct polymerases for leading- and lagging-strand replication, but how
they target their respective strands is uncertain. We reconstituted Saccharomyces cerevisiae …

The eukaryotic CMG (Cdc45, Mcm2–7, GINS) helicase consists of the Mcm2–7 hexameric
ring along with five accessory factors. The Mcm2–7 heterohexamer, like other hexameric …

DNA replication in eukaryotes is asymmetric, with separate DNA polymerases (Pol) dedicated
to bulk synthesis of the leading and lagging strands. Pol α/primase initiates primers on …

At the eukaryotic DNA replication fork, it is widely believed that the Cdc45–Mcm2–7–GINS (CMG)
helicase is positioned in front to unwind DNA and that DNA polymerases trail behind …

Maintenance of a stable cell volume and intracellular pH is critical for normal cell function.
Arguably, two of the most important ion transporters involved in these processes are the Na + /…