Background Antipsychotic therapy is widely used to treat behavioral problems in older adults
with dementia. Cohort studies evaluating the safety of antipsychotic therapy generally focus …

Background. Knowledge of any harm associated with living kidney donation guides informed
consent and living donor follow-up. Risk estimates in the literature are variable, and most …

Background: Reimbursement for outpatient prescription drugs is not mandated by the
Canada Health Act or any other federal legislation. Provincial governments independently …

Background Drug-reimbursement policies may have an adverse effect on patient outcomes
if they interfere with timely access to efficacious medications for acute medical conditions. …

PURPOSE: Recent observations in patients with atrial fibrillation who are receiving warfarin
suggest that concomitant treatment with a 3-hydroxy-3-methylglutaryl coenzyme A reductase …

Background The use of administrative databases in vascular injury research has been
increasing, but the validity of the diagnosis codes used in this research is uncertain. We assessed …

BACKGROUND: Current evidence suggests that statin use plays an important role in
improving adverse cardiovascular outcomes in patients with atherosclerosis. However, limited …

Objectives : This study assessed whether the results of major, potentially practice-altering
cardiovascular trials were influenced by the authors' self-declared financial conflicts of interest (…

Although there appears to be widespread support of evidence-based medicine as a basis
for rational prescribing, the challenges to it are signilicant and often justified. A multitude of …

Inhibitors of the renin-angiotensin system remain a cornerstone of cardiovascular
pharmacotherapy. Although angiotensin converting enzyme inhibitors (ACEIs) have been …