Cancers are often impossible to visually distinguish from normal tissue. This is critical for
brain cancer where residual invasive cancer cells frequently remain after surgery, leading to …

Both microglia, the resident myeloid cells of the CNS parenchyma, and infiltrating blood‐derived
macrophages participate in inflammatory responses in the CNS. Macrophages can be …

Single-cell technologies have enabled the characterization of the tumour microenvironment
at unprecedented depth and have revealed vast cellular diversity among tumour cells and …

Ion-channel gene defects are associated with a range of paroxysmal disorders, including
several monogenic epilepsy syndromes. Two autosomal dominant disorders present in the first …

Cancer stem cells are critical for cancer initiation, development, and treatment resistance.
Our understanding of these processes, and how they relate to glioblastoma heterogeneity, is …

Background 18 F-THK5351 is a quinoline-derived tau imaging agent with high affinity to paired
helical filaments (PHF). However, high levels of 18 F-THK5351 retention in brain regions …

Understanding the tumor immune microenvironment (TIME) promises to be key for optimal
cancer therapy, especially in triple-negative breast cancer (TNBC). Integrating spatial …

Glioblastomas (GBM) are highly motile cancers that invade through normal brain. In the
absence of curative chemotherapy this invasion, beyond surgical and radiotherapy margins, to …

Melanoma is an immunogenic cancer with a high response rate to immune checkpoint
inhibitors (ICIs). It harbors a high mutation burden compared with other cancers and, as a result, …

Purpose Pediatric glioblastoma (pGBM) is a rare, but devastating brain tumor. In contrast to
GBM in adults (aGBM), little is known about the mechanisms underlying its development. Our …