Demyelination in the adult CNS can be followed by extensive repair. However, in multiple
sclerosis, the differentiation of oligodendrocyte lineage cells present in demyelinated lesions …

… The past three decades have marked an exciting time for the field, as numerous neuroprotective
and neuroregenerative therapies have been translated from preclinical studies into …

The isolation or in vitro derivation of many human cell types remains challenging and
inefficient. Direct conversion of human pluripotent stem cells (hPSCs) by forced expression of …

Protecting axons from degeneration represents a major unmet need in the treatment of
myelin disorders and especially the currently untreatable secondary progressive stages of …

Demyelinating disorders of the central nervous system are among the most crippling
neurological diseases affecting patients at various stages of life. In the most prominent …

Study Design: Guideline development. Objectives: The objective of this study is to develop
guidelines that outline how to best manage (1) patients with mild, moderate, and severe …

The international bestseller--now with a new preface by author John Kotter. Millions worldwide
have read and embraced John Kotter's ideas on change management and leadership. …

Remyelination, the process by which new myelin sheaths are restored to demyelinated
axons, represents one of the most compelling examples of adult multipotent progenitor cells …

Microglia are cells of myeloid origin that populate the CNS during early development and form
the brain's innate immune cell type. They perform homoeostatic activity in the normal CNS…

An association between macrophages and remyelination efficiency has been observed in a
variety of different models of CNS demyelination. In order to test whether this association is …