Background Mechanical-ventilation strategies that use lower end-inspiratory (plateau)
airway pressures, lower tidal volumes (V T ), and higher positive end-expiratory pressures (PEEPs…

Background: This document provides evidence-based clinical practice guidelines on the use
of mechanical ventilation in adult patients with acute respiratory distress syndrome (ARDS). …

Context Low-tidal-volume ventilation reduces mortality in critically ill patients with acute lung
injury and acute respiratory distress syndrome. Instituting additional strategies to open …

A nonprobability sampling design is chosen when investigators cannot estimate the chance
of a given individual being included in the sample. Such designs enable investigators to …

Background A strategy of mechanical ventilation that limits airway pressure and tidal volume
while permitting hypercapnia has been recommended for patients with the acute respiratory …

Background Previous trials suggesting that high-frequency oscillatory ventilation (HFOV)
reduced mortality among adults with the acute respiratory distress syndrome (ARDS) were …

Rationale: Recent literature in mechanical ventilation includes strong evidence from
randomized trials. Little information is available regarding the influence of these trials on usual …

ContextRandomized clinical trials (RCTs) that stop earlier than planned because of apparent
benefit often receive great attention and affect clinical practice. Their prevalence, the …

Background Studies that have evaluated the use of intravenous vitamin C in adults with
sepsis who were receiving vasopressor therapy in the intensive care unit (ICU) have shown …

Rationale: The application of prone positioning for acute respiratory distress syndrome (ARDS)
has evolved, with recent trials focusing on patients with more severe ARDS, and applying …