User profiles for Michael A.S. Jewett

Michael Jewett

Professor of Surgery (Urology), University of Toronto
Verified email at jewett.ca
Cited by 31863

How many human proteoforms are there?

…, CG Huber, AR Ivanov, ON Jensen, MC Jewett… - Nature chemical …, 2018 - nature.com
Despite decades of accumulated knowledge about proteins and their post-translational
modifications (PTMs), numerous questions remain regarding their molecular composition and …

Cell-free protein synthesis: applications come of age

ED Carlson, R Gan, CE Hodgman, MC Jewett - Biotechnology advances, 2012 - Elsevier
Cell-free protein synthesis has emerged as a powerful technology platform to help satisfy
the growing demand for simple and efficient protein production. While used for decades as a …

Small renal mass

…, M Aron, DA Gervais, MAS Jewett - New England journal of …, 2010 - Mass Medical Soc
A 65-year-old man with a history of well-controlled hypertension presents for a follow-up visit
after an incidental finding of a small mass in the right kidney on an abdominal computed …

[HTML][HTML] Carbon-negative production of acetone and isopropanol by gas fermentation at industrial pilot scale

…, SD Simpson, SD Brown, C Leang, MC Jewett… - Nature …, 2022 - nature.com
Many industrial chemicals that are produced from fossil resources could be manufactured
more sustainably through fermentation. Here we describe the development of a carbon-…

The natural history of incidentally detected small renal masses

…, RA Rendon, MA Haider, FI Kondylis, MAS Jewett - Cancer, 2004 - Wiley Online Library
BACKGROUND The incidence of renal cell carcinoma (RCC) is increasing, largely due to the
widespread use of cross‐sectional imaging. Most renal tumors are detected incidentally as …

Precise manipulation of chromosomes in vivo enables genome-wide codon replacement

…, NB Reppas, CJ Emig, D Bang, SJ Hwang, MC Jewett… - Science, 2011 - science.org
We present genome engineering technologies that are capable of fundamentally reengineering
genomes from the nucleotide to the megabase scale. We used multiplex automated …

Active surveillance of small renal masses: progression patterns of early stage kidney cancer

MAS Jewett, K Mattar, J Basiuk, CG Morash, SE Pautler… - European urology, 2011 - Elsevier
Background Most early stage kidney cancers are renal cell carcinomas (RCCs), and most
are diagnosed incidentally by imaging as small renal masses (SRMs). Indirect evidence …

Mimicking the Escherichia coli cytoplasmic environment activates long‐lived and efficient cell‐free protein synthesis

MC Jewett, JR Swartz - Biotechnology and bioengineering, 2004 - Wiley Online Library
Cell‐free translation systems generally utilize high‐energy phosphate compounds to regenerate
the adenosine triphosphate (ATP) necessary to drive protein synthesis. This hampers …

Outcomes of small renal mass needle core biopsy, nondiagnostic percutaneous biopsy, and the role of repeat biopsy

…, H Chung, DA Shiff, K Fernandes, MAS Jewett - European urology, 2011 - Elsevier
BACKGROUND: Percutaneous needle core biopsy has become established in the management
of small renal masses ≤4cm (SRMs). Recent series have reported success rates of ≥…

Cell-free synthetic biology: thinking outside the cell

CE Hodgman, MC Jewett - Metabolic engineering, 2012 - Elsevier
Cell-free synthetic biology is emerging as a powerful approach aimed to understand, harness,
and expand the capabilities of natural biological systems without using intact cells. Cell-…