To identify circulating proteins influencing Coronavirus Disease 2019 (COVID-19) susceptibility
and severity, we undertook a two-sample Mendelian randomization (MR) study, rapidly …

Background Studies that have evaluated the use of intravenous vitamin C in adults with
sepsis who were receiving vasopressor therapy in the intensive care unit (ICU) have shown …

The efficacy of convalescent plasma for coronavirus disease 2019 (COVID-19) is unclear.
Although most randomized controlled trials have shown negative results, uncontrolled studies …

Background Conflicting observational evidence exists regarding the association between
the sex of red-cell donors and mortality among transfusion recipients. Evidence to inform …

Background Acute kidney injury ( AKI ) after cardiac surgery is associated with adverse
outcomes. Venous congestion can impair kidney function, but few tools are available to assess its …

Solid-organ transplantation is a life-saving treatment for end-stage organ disease in highly
selected patients. Alongside the tremendous progress in the last several decades, new …

Importance BK virus infection is a significant complication of modern immunosuppression
used in kidney transplantation. Viral reactivation occurs first in the urine (BK viruria) and is …

This 2023 Clinical Practice Guideline provides the biomedical definition of death based on
permanent cessation of brain function that applies to all persons, as well as …

Importance While red blood cells (RBCs) are administered to improve oxygen delivery and
patient outcomes, they also have been associated with potential harm. Unlike solid organ …

Background Angiotensin-converting enzyme inhibitors have been shown to reduce the risk
of end-stage renal disease and death in non-transplant patients with proteinuria. We …