The urokinase‐type plasminogen activator (u‐PA) system consists of the serine proteinases
plasmin and u‐PA; the serpin inhibitors α 2 ‐anti‐plasmin, PAI‐1 and PAI‐2; and the u‐PA …

Background: Carcinoembryonic antigen (CEA) is one of the most widely used tumor markers
worldwide. Its main application is mostly in gastrointestinal cancers, especially in colorectal …

… Michael J Duffy , Michael J Duffy … Catharine M Sturgeon, Michael J Duffy, Ulf-Håkan
Stenman, Hans Lilja, Nils Brünner, Daniel W Chan, Richard Babaian, Robert C Bast, Barry Dowell…

The matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases. Their
primary function is degradation of proteins in the extracellular matrix. Currently, at least 19 …

Background: Urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1) play
essential roles in tumor invasion and metastasis. High levels of both uPA and PAI-1 are …

A simple transformation is introduced which facilitates the evaluation of integrals over certain
square based pyramids or cubes in cases where the integrand has a singularity at a vertex.

The aim of this article is to present updated guidelines for the use of serum, tissue and faecal
markers in colorectal cancer (CRC). Lack of specificity and sensitivity preclude the use of …

Background: Although multiple serum-based tumor markers have been described for breast
cancer, such as CA 15-3, BR 27.29 (CA27.29), carcinoembryonic antigen (CEA), tissue …

Survivin is one of the most cancer-specific proteins identified to date, being upregulated in
almost all human tumors. Biologically, survivin has been shown to inhibit apoptosis, enhance …

The urokinase plasminogen activator (uPA) system consists of the serine protease uPA, its
glycolipid-anchored receptor, uPAR and its 2 serpin inhibitors, plasminogen activator inhibitor…