THE accumulation in brain of senile plaques containing β-amyloid protein (Aβ) is a defining
feature of Alzheimer's disease 1–3 . The amyloid precursor protein (APP) 4 from which Aβ is …

Crosstalk and complexity within signaling pathways and their perturbation by oncogenes
limit component-by-component approaches to understanding human disease. Network …

Vertebral strength, a key etiologic factor of osteoporotic fracture, may be affected by the
relative amount of vertically oriented trabeculae. To better understand this issue, we performed …

Sensitivity to the pungent vanilloid, capsaicin, defines a subpopulation of primary sensory
neurons that are mainly polymodal nociceptors. The recently cloned vanilloid receptor subtype …

Using immunocytochemistry and in situ hybridization, we have examined the expression of
brain-derived neurotrophic factor (BDNF) and of neurotrophin receptors in dorsal root …

Background CCR5 is the major coreceptor for human immunodeficiency virus (HIV). We
investigated whether site-specific modification of the gene (“gene editing”) — in this case, the …

We describe the design, construction, and performance of the Sloan Digital Sky Survey
telescope located at Apache Point Observatory. The telescope is a modified two-corrector Ritchey…

Alzheimer’s disease (AD) is a progressive neurodegenerative condition marked by a decline
in cognitive functions with no validated disease modifying treatment. It is critical for timely …

Interaction forces between single strands of DNA were measured with the atomic force
microscope by a procedure in which DNA oligonucleotides were covalently attached to a …

Homozygosity for the naturally occurring Δ32 deletion in the HIV co-receptor CCR5 confers
resistance to HIV-1 infection. We generated an HIV-resistant genotype de novo using …