User profiles for Michael Guo

Michael Guo

University of Pennsylvania
Verified email at pennmedicine.upenn.edu
Cited by 5623

Genetics of rheumatoid arthritis contributes to biology and drug discovery

…, D Mirel, EA Stahl, D Diogo, J Cui, K Liao, MH Guo… - Nature, 2014 - nature.com
A major challenge in human genetics is to devise a systematic strategy to integrate disease-associated
variants with diverse genomic and biological data sets to provide insight into …

[PDF][PDF] The polygenic and monogenic basis of blood traits and diseases

…, SB Felix, JS Floyd, L Broer, N Grarup, MH Guo, Q Guo… - Cell, 2020 - cell.com
Blood cells play essential roles in human health, underpinning physiological processes
such as immunity, oxygen transport, and clotting, which when perturbed cause a significant …

[PDF][PDF] Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations

…, MK Evans, JS Floyd, L Broer, N Grarup, MH Guo… - Cell, 2020 - cell.com
Most loci identified by GWASs have been found in populations of European ancestry (EUR).
In trans-ethnic meta-analyses for 15 hematological traits in 746,667 participants, including …

Using the time and motion method to study clinical work processes and workflow: methodological inconsistencies and a call for standardized research

K Zheng, MH Guo, DA Hanauer - Journal of the american …, 2011 - academic.oup.com
Objective To identify ways for improving the consistency of design, conduct, and results
reporting of time and motion (T&M) research in health informatics. Materials and methods We …

[PDF][PDF] The genetic landscape of Diamond-Blackfan anemia

…, JM Verboon, S Kazerounian, MH Guo… - The American Journal of …, 2018 - cell.com
Diamond-Blackfan anemia (DBA) is a rare bone marrow failure disorder that affects 7 out of
1,000,000 live births and has been associated with mutations in components of the ribosome…

Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes

…, J Flannick, P Shahinian, M Guo… - Proceedings of the …, 2014 - National Acad Sciences
Peroxisome proliferator-activated receptor gamma (PPARG) is a master transcriptional
regulator of adipocyte differentiation and a canonical target of antidiabetic thiazolidinedione …

Three-dimensional genome restructuring across timescales of activity-induced neuronal gene expression

JA Beagan, ED Pastuzyn, LR Fernandez, MH Guo… - Nature …, 2020 - nature.com
Neuronal activation induces rapid transcription of immediate early genes (IEGs) and longer-term
chromatin remodeling around secondary response genes (SRGs). Here, we use high-…

Interrogation of human hematopoiesis at single-cell and single-variant resolution

JC Ulirsch, CA Lareau, EL Bao, LS Ludwig, MH Guo… - Nature …, 2019 - nature.com
Widespread linkage disequilibrium and incomplete annotation of cell-to-cell state variation
represent substantial challenges to elucidating mechanisms of trait-associated genetic …

Practicality of intermittent fasting in humans and its effect on oxidative stress and genes related to aging and metabolism

MP Wegman, MH Guo, DM Bennion… - Rejuvenation …, 2015 - liebertpub.com
Caloric restriction has consistently been shown to extend life span and ameliorate aging-related
diseases. These effects may be due to diet-induced reactive oxygen species acting to up…

[PDF][PDF] Burden testing of rare variants identified through exome sequencing via publicly available control data

MH Guo, L Plummer, YM Chan, JN Hirschhorn… - The American Journal of …, 2018 - cell.com
The genetic causes of many Mendelian disorders remain undefined. Factors such as lack of
large multiplex families, locus heterogeneity, and incomplete penetrance hamper these …