The human HDAC (histone deacetylase) family, a well-validated anticancer target, plays a
key role in the control of gene expression through regulation of transcription. While HDACs …

Recently, mutations in the Met tyrosine kinase receptor have been identified in both hereditary
and sporadic forms of papillary renal carcinoma. We have introduced the corresponding …

Platelet-derived growth factor (PDGF) has been directly implicated in developmental and
physiological processes 1, 2, 3, 4, 5, as well as in human cancer, fibrotic diseases and …

Hepatocyte growth factor (HGF) is a ligand of the receptor tyrosine kinase encoded by the c-Met
protooncogene. HGF/Met signaling has multifunctional effects on various cell types. We …

Background Tumour mutational status is an important determinant of the response of metastatic
colorectal cancer to targeted treatments. However, the genotype of the tissue obtained at …

Using double immunofluorescence staining and quantitative confocal laser scan microscopy,
we show that the intensity of hepatocyte growth factor/scatter factor (HGF/SF) and Met …

The Met tyrosine kinase receptor is a widely expressed molecule which mediates pleiotropic
cellular responses following activation by its ligand, hepatocyte growth factor/scatter factor (…

Hepatocyte growth factor/scatter factor (HGF/SF) is a pleiotropic effector of cells expressing
the Met tyrosine kinase receptor. While HGF/SF-Met signaling clearly plays a role in a variety …

PURPOSE: Advanced melanoma is a highly drug-refractory neoplasm representing a
significant unmet medical need. We sought to identify melanoma-associated cell surface …

Hereditary papillary renal carcinoma (HPRC) is a newly recognized inherited disorder
characterized by a predisposition to develop multiple bilateral papillary renal carcinomas. …