Genes for familial hemiplegic migraine (FHM) and episodic ataxia type-2 (EA-2) have been
mapped to chromosome 19p13. We characterized a brain-specific P/Q-type Ca 2+ channel …

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INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological
comorbidity, inciting debate about their etiologic overlap. However, detailed study of …

Facial expression is widely used as a measure of pain in infants; whether nonhuman animals
display such pain expressions has never been systematically assessed. We developed the …

Background The triptans, selective serotonin 5-HT 1B/1D agonists, are very effective acute
migraine drugs with a well-developed scientific rationale. Seven different triptans will soon be …

ContextClinical series have suggested an increased prevalence of cerebral infarction and
white matter lesions (WMLs) in migraine patients. It is not known whether these lesions are …

Background Familial hemiplegic migraine is an autosomal dominant severe subtype of
migraine with aura characterised by some degree of hemiparesis during the attacks. So far, …

Migraine is a common, disabling, multifactorial, episodic neurovascular disorder of unknown
etiology. Familial hemiplegic migraine type 1 (FHM-1) is a Mendelian subtype of migraine …

Migraine is a debilitating neurological disorder affecting around one in seven people worldwide,
but its molecular mechanisms remain poorly understood. There is some debate about …

The triptans, selective serotonin 5-HT 1B/1D agonists, are very effective acute migraine drugs.
Soon, seven different triptans will be clinically available at 13 different oral doses, making …