Tumor recurrence following treatment remains a major clinical challenge. Evidence from
xenograft models and human trials indicates selective enrichment of cancer-initiating cells (CICs…

Huntington’s disease (HD) is a hereditary neurodegenerative disorder caused by expansion
of cytosine-adenine-guanine (CAG) trinucleotide repeats in the huntingtin (HTT) gene. …

A formal [3 + 3] cycloaddition strategy for constructing complex heterocycles is reviewed here.
This formal cycloaddition involves condensation of α,β‐unsaturated iminium salts with 1,3‐…

Purpose: Current prostate cancer management calls for identifying novel and more effective
therapies. Self-renewing tumor-initiating cells (TICs) hold intrinsic therapy resistance and …

Lung cancer is the most common cause of cancer deaths. The expression of the transcription
factor C/EBPα (CCAAT/enhancer binding protein α) is frequently lost in non–small cell lung …

BMI-1, also known as a stem cell factor, is frequently upregulated in several malignancies.
Elevated expression of BMI-1 correlates with poor prognosis and is therefore considered a …

… Nadiya Sydorenko … Nadiya Sydorenko - Department of Chemistry, University of
Minnesota, Minneapolis, Minnesota 55455 … Cole, Nadiya Sydorenko, Jacob J. Swidorski …

A detailed account on chiral secondary amine salt promoted enantioselective intramolecular
formal aza-[3 + 3] cycloadditions is described here for the first time. The dependence of …

… Nadiya Sydorenko … Nadiya Sydorenko - Division of Pharmaceutical Sciencies and
Department of Chemistry, Rennebohm Hall, 777 Highland Avenue, University of Wisconsin …

Medulloblastoma (MB) is the most frequent malignant pediatric brain tumor, representing 20%
of newly diagnosed childhood central nervous system malignancies. Although advances …