Due to practical and ethical concerns associated with human experimentation, animal
models have been essential in cancer research. However, the average rate of successful …

Background: Community-acquired pneumonia (CAP) is common and often severe. Purpose:
To examine the effect of adjunctive corticosteroid therapy on mortality, morbidity, and …

Background: Arthroscopic surgery for degenerative meniscal tears is a commonly performed
procedure, yet the role of conservative treatment for these patients is unclear. This …

Previous meta-analyses of methylprednisolone (MPS) for patients with acute traumatic spinal
cord injuries (TSCIs) have not addressed confidence in the quality of evidence used for …

In prior analyses of the effectiveness of methylprednisolone for the treatment of patients with
acute traumatic spinal cord injuries (TSCIs), the prognostic importance of patients' …

Background context Randomized controlled trials (RCTs) are the most trustworthy source
for evaluating treatment effects, but RCTs of spine surgery interventions often produce …

Objective To determine the effects and complications of arthroscopic surgery compared with
conservative management strategies in patients with degenerative knee disease. Design …

Background: High-quality, evidence-based orthopaedic care relies on the generation and
translation of robust research evidence. The Fragility Index is a novel method for evaluating …

Background: Giant cell tumor of bone is a primary bone tumor that is treated surgically and is
associated with high morbidity in many cases. This tumor consists of giant cells expressing …

Electrical stimulation is a common adjunct used to promote bone healing; its efficacy, however,
remains uncertain. We conducted a meta-analysis of randomized sham-controlled trials …